Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20227519 | 0.92 | KMT2A (0.56) | KMT2AMAPK1PDE10AKDM4EATM | |
| SCHEMBL20227515 | 0.92 | KMT2A (0.58) | KMT2AMAPK1PDE10AKDM4EATM | |
| SCHEMBL20227682 | 0.91 | KMT2A (0.56) | KMT2AMAPK1KDM4EATML3MBTL1 | |
| SCHEMBL20227514 | 0.91 | KMT2A (0.51) | KMT2AMAPK1PDE10AKDM4EATM | |
| SCHEMBL20227686 | 0.91 | KMT2A (0.55) | KMT2AMAPK1KDM4EATML3MBTL1 | |
| SCHEMBL26046196 | 0.90 | KMT2A (0.49) | KMT2AMAPK1PDE10AKDM4EATM | |
| SCHEMBL20227701 | 0.90 | KMT2A (0.52) | KMT2AMAPK1KDM4EATML3MBTL1 | |
| SCHEMBL20227732 | 0.90 | KMT2A (0.47) | KMT2AMAPK1PDE10AKDM4EATM | |
| SCHEMBL20227709 | 0.90 | KMT2A (0.53) | KMT2AMAPK1PDE10AKDM4EATM | |
| SCHEMBL20227689 | 0.89 | KMT2A (0.56) | KMT2AMAPK1KDM4EATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11713319-B2 | Compounds having valerolactam structures | MERCK PATENT GMBH (DE) | 2023-08-01 | — | — | US | disclosed |
| US-11713319-B2 | Compounds having valerolactam structures | MERCK PATENT GMBH (DE) | 2023-08-01 | — | — | US | disclosed |
| US-20200031827-A1 | COMPOUNDS HAVING VALEROLACTAM STRUCTURES | MERCK PATENT GMBH (DE) | 2020-01-30 | — | — | US | disclosed |
| WO-2018099846-A1 | COMPOUNDS HAVING VALEROLACTAM STRUCTURES | MERCK PATENT GMBH (DE) | 2018-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11713319-B2 | Compounds having valerolactam structures | ACE, CYP3A4, CYP2D6 | KMT2A 1161/4885MAPK1 2970/4885PDE10A 3215/4885 |
| US-20200031827-A1 | COMPOUNDS HAVING VALEROLACTAM STRUCTURES | ACE, CYP3A4, CYP2D6 | KMT2A 1161/4885MAPK1 2970/4885PDE10A 3215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.