SCHEMBL20237382

SCHEMBL20237382

CCC(c1ccccc1)N1Cc2cc3c(cc2C[C@H]1C(=O)NC(Cc1ccc(-c2ccc(C#N)cc2)cc1)C(=O)O)N(C)C(=O)[C@@H](c1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)O3

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GLP1R P43220 20/20 1.00
AMY1A P0DUB6 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1151397 1.00 GLP1R (1.00) GLP1RAMY1A
SCHEMBL3293485 1.00 GLP1R (1.00) GLP1RAMY1A
SCHEMBL1151245 1.00 GLP1R (1.00) GLP1RAMY1A
SCHEMBL1151471 1.00 GLP1R (1.00) GLP1RAMY1A
SCHEMBL1151988 1.00 GLP1R (1.00) GLP1RAMY1A
SCHEMBL12798935 1.00 GLP1R (1.00) GLP1RAMY1A
SCHEMBL1151240 1.00 GLP1R (1.00) GLP1RAMY1A
SCHEMBL1151242 1.00 GLP1R (1.00) GLP1RAMY1A
SCHEMBL1151480 1.00 GLP1R (1.00) GLP1RAMY1A
SCHEMBL13590579 1.00 GLP1R (1.00) GLP1RAMY1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3790549-A1 THERAPEUTIC USES OF GLP1R AGONISTS vTv Therapeutics LLC (US) 2021-03-17 EP claimed
WO-2019217165-A1 THERAPEUTIC USES OF GLP1R AGONISTS VTV THERAPEUTICS LLC (US) 2019-11-14 WO claimed
EP-3790549-A1 THERAPEUTIC USES OF GLP1R AGONISTS vTv Therapeutics LLC (US) 2021-03-17 EP disclosed
WO-2019217165-A1 THERAPEUTIC USES OF GLP1R AGONISTS VTV THERAPEUTICS LLC (US) 2019-11-14 WO disclosed
EP-2945618-B1 COMBINATIONS OF A GLP1R AGONIST AND METFORMIN AND USE THEREOF FOR THE TREATMENT OF TYPE 2 DIABETES AND OTHER DISORDERS VTV THERAPEUTICS LLC (US) 2018-06-13 EP disclosed