Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 13/20 | 1.00 |
| ▸ | SCN1A | P35498 | 11/20 | 1.00 |
| ▸ | SCN5A | Q14524 | 11/20 | 1.00 |
| ▸ | SCN1B | Q07699 | 6/20 | 1.00 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.63 |
| ▸ | SCN4A | P35499 | 1/20 | 0.63 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.63 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.63 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20238762 | 1.00 | SCN8A (1.00) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| SCHEMBL20238204 | 0.84 | SCN8A (1.00) | SCN8ASCN1ASCN5ASCN1B | |
| SCHEMBL3159821 | 0.84 | SCN1A (0.72) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| SCHEMBL3173424 | 0.84 | SCN1A (0.72) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| SCHEMBL28981422 | 0.81 | SCN1A (0.67) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| SCHEMBL28981423 | 0.80 | SCN3A (0.67) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| SCHEMBL29089178 | 0.79 | SCN8A (0.65) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| SCHEMBL29089177 | 0.79 | SCN8A (0.65) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| SCHEMBL29089327 | 0.79 | SCN8A (0.65) | SCN8ASCN1ASCN5ASCN1BSCN3A | |
| SCHEMBL13154447 | 0.79 | SCN8A (0.65) | SCN8ASCN1ASCN5ASCN1BSCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110325531-B | Benzenesulfonamides and their use as therapeutic agents | 泽农医药公司 | 2022-05-27 | — | — | CN | disclosed |
| US-11174268-B2 | Benzenesulfonamide compouds and their use as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2021-11-16 | — | — | US | disclosed |
| US-20210171537-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2021-06-10 | — | — | US | disclosed |
| EP-3551626-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | Xenon Pharmaceuticals Inc. (CA) | 2019-10-16 | — | — | EP | disclosed |
| US-20180162868-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2018-06-14 | — | — | US | disclosed |
| WO-2018106284-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2018-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11174268-B2 | Benzenesulfonamide compouds and their use as therapeutic agents | KCND2, SCN1A, CACNA1D | SCN8A 20/4885SCN1A 2/4885SCN5A 42/4885 |
| US-20210171537-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | SCN1A, SCN1B, SCN2B | SCN8A 11/4885SCN1A 1/4885SCN5A 10/4885 |
| US-20180162868-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | SCN1A, SCN1B, SCN2B | SCN8A 11/4885SCN1A 1/4885SCN5A 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.