Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.66 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | HTR7 | P34969 | 4/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2023970 | 1.00 | KCNH2 (0.66) | KCNH2HSP90AB1HTR1AHTR7DRD2 | |
| SCHEMBL2021579 | 0.88 | KCNH2 (0.75) | KCNH2HTR1AHTR7DRD2MAPT | |
| SCHEMBL2021576 | 0.88 | KCNH2 (0.75) | KCNH2HTR1AHTR7DRD2MAPT | |
| SCHEMBL2022015 | 0.87 | KCNH2 (0.68) | KCNH2MAPTABCB1 | |
| SCHEMBL2022012 | 0.87 | KCNH2 (0.68) | KCNH2MAPTABCB1 | |
| SCHEMBL2021942 | 0.87 | KCNH2 (0.68) | KCNH2HTR1AHTR7DRD2MAPT | |
| SCHEMBL2024246 | 0.87 | KCNH2 (0.68) | KCNH2HTR1AHTR7DRD2MAPT | |
| SCHEMBL2021940 | 0.87 | KCNH2 (0.68) | KCNH2HTR1AHTR7DRD2MAPT | |
| SCHEMBL2017439 | 0.85 | KCNH2 (0.82) | KCNH2HTR7MAPTKDM4E | |
| SCHEMBL2024416 | 0.85 | KCNH2 (0.82) | KCNH2HTR7MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170334-B1 | NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION | UNIV EMORY (US) | 2021-03-17 | — | — | EP | disclosed |
| US-9079852-B2 | NMDA receptor antagonists for neuroprotection | EMORY UNIVERSITY (US) | 2015-07-14 | — | — | US | disclosed |
| US-20140031363-A1 | NMDA Receptor Antagonists for Neuroprotection | LIOTTA DENNIS C (US) | 2014-01-30 | — | — | US | disclosed |
| US-8420680-B2 | NMDA receptor antagonists for neuroprotection | EMORY UNIVERSITY (US) | 2013-04-16 | — | — | US | disclosed |
| US-20110160223-A1 | NMDA Receptor Antagonists for the Treatment of Neuropsychiatric Disorders | EMORY UNIVERSITY | 2011-06-30 | — | — | US | disclosed |
| US-20090253710-A1 | NMDA Receptor Antagonists for Neuroprotection | EMORY UNIVERSITY | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253710-A1 | NMDA Receptor Antagonists for Neuroprotection | GRIN1, GRIN2C, GRIK1 | KCNH2 137/4885HSP90AB1 3316/4885HTR1A 1304/4885 |
| US-20110160223-A1 | NMDA Receptor Antagonists for the Treatment of Neuropsychiatric Disorders | GRIN2A, GRIN2B, GRIN1 | KCNH2 469/4885HSP90AB1 4207/4885HTR1A 68/4885 |
| US-20140031363-A1 | NMDA Receptor Antagonists for Neuroprotection | GRIN1, GRIN2C, GRIK1 | KCNH2 135/4885HSP90AB1 3321/4885HTR1A 1268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.