Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 19/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20240215 | 0.86 | PDE2A (1.00) | PDE2A | |
| SCHEMBL20240165 | 0.76 | PDE2A (1.00) | PDE2A | |
| SCHEMBL20240257 | 0.75 | PDE2A (1.00) | PDE2A | |
| SCHEMBL20240249 | 0.64 | PDE2A (1.00) | PDE2A | |
| SCHEMBL20240248 | 0.62 | PDE2A (1.00) | PDE2A | |
| SCHEMBL20240222 | 0.61 | PDE2A (0.76) | PDE2A | |
| SCHEMBL20240173 | 0.60 | PDE2A (1.00) | PDE2A | |
| SCHEMBL20240247 | 0.59 | PDE2A (1.00) | PDE2A | |
| SCHEMBL13828410 | 0.58 | HTR2C (0.46) | PDE2A | |
| SCHEMBL10307718 | 0.58 | PDE2A (0.43) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647727-B2 | Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2020-05-12 | — | — | US | claimed |
| US-20180162874-A1 | SUBSTITUTED PYRAZOLO/IMIDAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-06-14 | — | — | US | claimed |
| EP-3313852-B1 | SUBSTITUTED PYRAZOLO/IMIDAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2021-01-20 | — | — | EP | disclosed |
| US-10647727-B2 | Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2020-05-12 | — | — | US | disclosed |
| US-10647727-B2 | Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2020-05-12 | — | — | US | disclosed |
| US-20180162874-A1 | SUBSTITUTED PYRAZOLO/IMIDAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-06-14 | — | — | US | disclosed |
| US-20180162874-A1 | SUBSTITUTED PYRAZOLO/IMIDAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-06-14 | — | — | US | disclosed |
| US-20180162874-A1 | SUBSTITUTED PYRAZOLO/IMIDAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162874-A1 | SUBSTITUTED PYRAZOLO/IMIDAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | PDE2A, PDE12, PDE4D | PDE2A 1/4885HDAC1 291/4885HDAC8 482/4885 |
| US-10647727-B2 | Substituted pyrazolo/imidazolo bicyclic compounds as PDE2 inhibitors | PDE2A, PDE12, PDE4D | PDE2A 1/4885HDAC1 291/4885HDAC8 482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.