Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 7/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.59 |
| ▸ | ALPI | P09923 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | XIAP | P98170 | 1/20 | 0.59 |
| ▸ | NOS3 | P29474 | 3/20 | 0.58 |
| ▸ | NOS1 | P29475 | 3/20 | 0.58 |
| ▸ | NOS2 | P35228 | 3/20 | 0.58 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.57 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.57 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.57 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.56 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL202409 | 1.00 | SLC7A5 (0.65) | SLC7A5PTGS1ALPIPKMXIAP | |
| SCHEMBL288337 | 1.00 | SLC7A5 (0.65) | SLC7A5PTGS1ALPIPKMXIAP | |
| SCHEMBL31538733 | 1.00 | SLC7A5 (0.65) | SLC7A5PTGS1ALPIPKMXIAP | |
| SCHEMBL18049406 | 0.94 | SLC7A5 (0.59) | SLC7A5PTGS1ALPIPKMXIAP | |
| SCHEMBL7371250 | 0.90 | SLC7A5 (0.60) | SLC7A5PTGS1ALPIPKMXIAP | |
| SCHEMBL667717 | 0.87 | SLC7A5 (0.68) | SLC7A5PTGS1ALPIPKMXIAP | |
| SCHEMBL29637609 | 0.87 | SLC7A5 (0.68) | SLC7A5PTGS1ALPIPKMXIAP | |
| SCHEMBL21690081 | 0.87 | SLC7A5 (0.68) | SLC7A5PTGS1ALPIPKMXIAP | |
| SCHEMBL30834634 | 0.87 | SLC7A5 (0.68) | SLC7A5PTGS1ALPIPKMXIAP | |
| SCHEMBL667716 | 0.87 | SLC7A5 (0.68) | SLC7A5PTGS1ALPIPKMXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 274 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE46424-E1 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG (DE) | 2017-06-06 | — | — | US | claimed |
| US-8088921-B2 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG (DE) | 2012-01-03 | — | — | US | claimed |
| US-7951943-B2 | Method for preparing and purifying 3-hydroxyamidinophenylalanine compounds | WILEX AG (DE) | 2011-05-31 | — | — | US | claimed |
| EP-2316830-A2 | N-sulphonylated amino acid derivatives and their use as matriptase inhibitors | The Medicines Company (Leipzig) GmbH (DE) | 2011-05-04 | — | — | EP | claimed |
| US-20110087025-A1 | METHOD FOR PRODUCING 3-AMIDINOPHENYLALANINE DERIVATIVES | WILEX AG (DE) | 2011-04-14 | — | — | US | claimed |
| JP-4653100-B2 | — | — | 2011-03-16 | — | — | JP | claimed |
| US-7884206-B2 | N-alpha-2,4,6-triisopropylphenylsulfonyl-3-cyano-(L)-phenylalanine-4-ethoxycarbonyl piperazide dissolved in ethanol, mixed with hydroxylamine hydrochloride to produce N- alpha -2,4,6-Triisopropylphenylsulfonyl-3-amidino-(L)-phenylalanine-4-ethoxycarbonyl piperazide hydrochloride, reduction with H2, Pd/C | WILEX AG (DE) | 2011-02-08 | — | — | US | claimed |
| US-20110002992-A1 | N-SULPHONYLATED AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2011-01-06 | — | — | US | claimed |
| US-7772251-B2 | N-sulphonylated amino acid derivatives, method for the production and use thereof | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2010-08-10 | — | — | US | claimed |
| EP-1799665-B1 | METHOD FOR CLEANING 3-HYDROXYAMIDINOPHENYLALANINE DERIVATIVES BY THE PRECIPITATION AND RECRYSTALLISATION OF A SALT AND AN AROMATIC SULPHONIC ACID | WILEX AG (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-1480963-B1 | METHOD FOR PRODUCING 3-AMIDINOPHENYLALANINE DERIVATIVES | WILEX AG (DE) | 2007-05-02 | — | — | EP | claimed |
| US-20070055065-A1 | N-sulphonylated amino acid derivatives, method for the production and use thereof | CURACYTE CHEMISTRY GMBH (DE) | 2007-03-08 | — | — | US | claimed |
| JP-2007500734-A | — | — | 2007-01-18 | — | — | JP | claimed |
| EP-1651597-A2 | N-SULPHONYLATED AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF | Curacyte Chemistry GmbH (DE) | 2006-05-03 | — | — | EP | claimed |
| US-20050176962-A1 | Method for producing 3-amidinophenylalanine derivatives | WILEX AG (DE) | 2005-08-11 | — | — | US | claimed |
| EP-1480963-A1 | METHOD FOR PRODUCING 3-AMIDINOPHENYLALANINE DERIVATIVES | Pentapharm AG (CH) | 2004-12-01 | — | — | EP | claimed |
| WO-2004101507-A2 | N-SULPHONYLATED AMINO ACID DERIVATIVES AND USE THEREOF AS MATRIPTASE INHIBITORS | CURACYTE CHEMISTRY GMBH (DE) | 2004-11-25 | — | — | WO | claimed |
| US-6649593-B1 | Amino acid derivatives including serine, leucine, valine, arginine, asparginine, methionine, glycine and phenylalanine units; S1 protease inhibition; modulation of cholesterol homeostasis in cells | TULARIK INC. | 2003-11-18 | — | — | US | claimed |
| WO-2003072559-A1 | METHOD FOR PRODUCING 3-AMIDINOPHENYLALANINE DERIVATIVES | PENTAPHARM AG (CH) | 2003-09-04 | — | — | WO | claimed |
| WO-2001027138-A2 | MODULATORS OF SREBP PROCESSING | TULARIK INC. (US) | 2001-04-19 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070055065-A1 | N-sulphonylated amino acid derivatives, method for the production and use thereof | DNPEP, ANPEP, PEPD | SLC7A5 116/4885PTGS1 769/4885ALPI 2100/4885 |
| US-20110002992-A1 | N-SULPHONYLATED AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF | DNPEP, ANPEP, PEPD | SLC7A5 116/4885PTGS1 769/4885ALPI 2100/4885 |
| US-20110087025-A1 | METHOD FOR PRODUCING 3-AMIDINOPHENYLALANINE DERIVATIVES | PAH, APEH, DAO | SLC7A5 466/4885PTGS1 1395/4885ALPI 480/4885 |
| US-20050176962-A1 | Method for producing 3-amidinophenylalanine derivatives | APEH, ANPEP, PAH | SLC7A5 750/4885PTGS1 1070/4885ALPI 315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.