Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 15/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 15/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2028167 | 0.92 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3TP53 | |
| SCHEMBL2027733 | 0.87 | GRM2 (0.47) | SLC6A2SLC6A4SLC6A3HTR2C | |
| SCHEMBL2024501 | 0.84 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2019312 | 0.79 | KCNH2 (0.41) | TP53HTR2CHTR2B | |
| SCHEMBL2022164 | 0.78 | GRM2 (0.54) | HTR2C | |
| SCHEMBL2020458 | 0.77 | SLC6A4 (0.36) | SLC6A2SLC6A4SLC6A3TP53 | |
| SCHEMBL2020651 | 0.76 | ERCC1 (0.42) | — | |
| SCHEMBL2022463 | 0.73 | HTR2A (0.38) | SLC6A4TP53HTR2CHTR2B | |
| SCHEMBL2024695 | 0.73 | MEN1 (0.39) | HTR2CHTR2B | |
| SCHEMBL2027229 | 0.71 | ERCC1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2357169-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | AstraZeneca AB (SE) | 2011-08-17 | — | — | EP | disclosed |
| US-7968570-B2 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2011-06-28 | — | — | US | disclosed |
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275578-A1 | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators | GRM1, GRIN1, GRM3 | SLC6A2 835/4885SLC6A4 465/4885SLC6A3 533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.