Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.43 |
| ▸ | CDK1 | P06493 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | CDK7 | P50613 | 3/20 | 0.43 |
| ▸ | CDK9 | P50750 | 3/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | MOGAT2 | Q3SYC2 | 2/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20249376 | 0.84 | PDCD1 (0.47) | CDK4CDK1CDK2CDK7CDK9 | |
| SCHEMBL18806181 | 0.82 | CDK4 (0.40) | CDK4CDK1CDK2CDK7CDK9 | |
| SCHEMBL22966559 | 0.82 | CDK4 (0.42) | CDK4CDK2CDK6LMNAPOLB | |
| SCHEMBL18819904 | 0.82 | CDK4 (0.41) | CDK4LMNAPOLBMAPTPDCD1 | |
| SCHEMBL18806194 | 0.82 | ADORA2A (0.37) | CDK4CDK1CDK2CDK7CDK9 | |
| SCHEMBL20249391 | 0.82 | CDK4 (0.42) | CDK4CDK1CDK2CDK7CDK9 | |
| SCHEMBL18291526 | 0.81 | CDK4 (0.40) | CDK4CDK1CDK2CDK7CDK9 | |
| SCHEMBL29591564 | 0.81 | CDK4 (0.40) | CDK4CDK1CDK2CDK7CDK9 | |
| Hydrochloric Acid SCHEMBL29591446 | 0.80 | CDK4 (0.40) | CDK4CDK1CDK2CDK7CDK9 | |
| SCHEMBL18806155 | 0.80 | CDK4 (0.44) | CDK4CDK2CDK6HTR7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | TEIJIN PHARMA LIMITED (JP) | 2018-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180161329-A1 | PYRIDO[3,4-D]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | CDK4, CDK6, CDK16 | CDK4 1/4885CDK1 8/4885CDK2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.