Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19372449 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2NPC1RAB9AHDAC2MEN1 | |
| SCHEMBL18494908 | 0.88 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL18499692 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23054325 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL24279731 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23054326 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL15382668 | 0.85 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL20056881 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL14870877 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL18431280 | 0.84 | SMN1; SMN2 (0.44) | SMN1; SMN2NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018107116-A1 | METHODS OF REDUCING TOXICITY OF ANTIBODY DRUG CONJUGATES, AND COMPOSITIONS PRODUCED THEREBY | ABBVIE STEMCENTRX LLC (US) | 2018-06-14 | — | — | WO | disclosed |