Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 12/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20258365 | 0.93 | TOP1 (0.84) | TOP1KCNH2KDM4EALDH1A1POLB | |
| SCHEMBL20258407 | 0.92 | TOP1 (0.78) | TOP1KCNH2KDM4EALDH1A1POLB | |
| SCHEMBL21787290 | 0.90 | TOP1 (0.90) | TOP1KCNH2KDM4EALDH1A1POLB | |
| SCHEMBL20258379 | 0.89 | TOP1 (0.88) | TOP1KCNH2KDM4EALDH1A1POLB | |
| SCHEMBL20258411 | 0.89 | TOP1 (0.88) | TOP1KCNH2KDM4EALDH1A1POLB | |
| SCHEMBL20258486 | 0.89 | TOP1 (0.71) | TOP1KCNH2KDM4EALDH1A1POLB | |
| SCHEMBL20242745 | 0.88 | TOP1 (1.00) | TOP1KCNH2KDM4EALDH1A1POLB | |
| SCHEMBL20258348 | 0.88 | TOP1 (1.00) | TOP1KCNH2KDM4EALDH1A1POLB | |
| SCHEMBL20242743 | 0.88 | TOP1 (1.00) | TOP1KCNH2KDM4EALDH1A1POLB | |
| SCHEMBL21786930 | 0.84 | TOP1 (0.81) | TOP1KCNH2KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018107112-A1 | QUINOLONE-BASED COMPOUNDS WITH ANTICANCER ACTIVITY | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2018-06-14 | — | — | WO | disclosed |