Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 5/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16756388 | 0.90 | PPARD (0.38) | PPARDPPARATLR7TNFHDAC1 | |
| SCHEMBL15560797 | 0.87 | GRIN1 (0.41) | PPARDPPARATLR7GRIN1GRIN2B | |
| SCHEMBL20240522 | 0.87 | GRIN1 (0.41) | TNFHDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL16756311 | 0.87 | TNF (0.46) | TLR7TNF | |
| SCHEMBL16756580 | 0.84 | TLR7 (0.44) | PPARDPPARATLR7HDAC1HDAC8 | |
| SCHEMBL18149071 | 0.84 | TNF (0.43) | PPARDPPARATLR7TNF | |
| SCHEMBL15560205 | 0.83 | GRIN1 (0.47) | PPARDPPARATLR7TNFGRIN1 | |
| SCHEMBL15551375 | 0.83 | TNF (0.41) | PPARDPPARATLR7TNFHDAC1 | |
| SCHEMBL15560795 | 0.82 | HDAC1 (0.40) | PPARDPPARATLR7HDAC1HDAC8 | |
| SCHEMBL22420489 | 0.81 | PPARD (0.38) | PPARDPPARATLR7HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551624-B1 | A SUBSTITUTED BENZIMIDAZOLE DERIVATIVE AS A MODULATOR OF TNF ACTIVITY | UCB Biopharma SRL (BE) | 2021-01-20 | — | — | EP | disclosed |
| WO-2018104534-A1 | A SUBSTITUTED BENZIMIDAZOLE DERIVATIVE AS A MODULATOR OF TNF ACTIVITY | UCB BIOPHARMA SPRL (BE) | 2018-06-14 | — | — | WO | disclosed |