Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.33 |
| ▸ | SKP1 | P63208 | 1/20 | 0.33 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 4/20 | 0.32 |
| ▸ | BACE1 | P56817 | 3/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.32 |
| ▸ | JAK1 | P23458 | 3/20 | 0.31 |
| ▸ | CCKAR | P32238 | 1/20 | 0.31 |
| ▸ | CCKBR | P32239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20287567 | 0.91 | GAA (0.39) | GAAEPHX2NFKB1NFKB2RELA | |
| SCHEMBL25760377 | 0.88 | GAA (0.41) | GAAEPHX2NFKB1NFKB2RELA | |
| SCHEMBL25766051 | 0.87 | GAA (0.40) | GAAEPHX2NFKB1NFKB2RELA | |
| SCHEMBL25759562 | 0.82 | GAA (0.42) | GAAEPHX2NFKB1NFKB2RELA | |
| SCHEMBL26961952 | 0.81 | GAA (0.41) | GAAEPHX2NFKB1NFKB2RELA | |
| SCHEMBL20264133 | 0.81 | SMN1; SMN2 (0.48) | GAAEPHX2NFKB1NFKB2RELA | |
| SCHEMBL26962099 | 0.81 | GAA (0.44) | GAAEPHX2NFKB1NFKB2RELA | |
| SCHEMBL20263891 | 0.80 | GAA (0.40) | GAAEPHX2NFKB1NFKB2RELA | |
| SCHEMBL20263999 | 0.80 | GAA (0.40) | GAAEPHX2NFKB1NFKB2RELA | |
| SCHEMBL26962143 | 0.80 | GAA (0.40) | GAAEPHX2NFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472341-B2 | Bicyclic tetrahydrothiazepine derivatives useful for the treatment of neoplastic and/or infectious diseases | APEIRON BIOLOGICS AG (AT) | 2019-11-12 | — | — | US | disclosed |
| US-20180170888-A1 | BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEOPLASTIC AND/OR INFECTIOUS DISEASES | APEIRON BIOLOGICS GMBH (AT) | 2018-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472341-B2 | Bicyclic tetrahydrothiazepine derivatives useful for the treatment of neoplastic and/or infectious diseases | CCNT2, HRH4, HRH3 | GAA 3737/4885EPHX2 1697/4885NFKB1 2445/4885 |
| US-20180170888-A1 | BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES USEFUL FOR THE TREATMENT OF NEOPLASTIC AND/OR INFECTIOUS DISEASES | CCNT2, HRH4, HRH3 | GAA 3737/4885EPHX2 1697/4885NFKB1 2445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.