Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 17/20 | 1.00 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18249304 | 1.00 | PDE2A (1.00) | PDE2AEPHX2SLC7A5TRPM8 | |
| Hydrochloric Acid SCHEMBL17781163 | 0.98 | PDE2A (0.97) | PDE2AEPHX2SLC7A5TRPM8 | |
| Hydrochloric Acid SCHEMBL16563563 | 0.98 | PDE2A (0.97) | PDE2AEPHX2SLC7A5TRPM8 | |
| Hydrochloric Acid SCHEMBL17781188 | 0.83 | PDE2A (0.71) | PDE2AEPHX2SLC7A5 | |
| SCHEMBL20280039 | 0.82 | PDE2A (0.70) | PDE2AEPHX2SLC7A5 | |
| SCHEMBL16043107 | 0.81 | PDE2A (0.68) | PDE2AEPHX2SLC7A5 | |
| SCHEMBL19876596 | 0.81 | PDE2A (0.68) | PDE2AEPHX2SLC7A5 | |
| Hydrochloric Acid SCHEMBL17781126 | 0.81 | PDE2A (0.68) | PDE2A | |
| Hydrochloric Acid SCHEMBL17781077 | 0.80 | PDE2A (0.67) | PDE2AEPHX2SLC7A5 | |
| SCHEMBL23112452 | 0.79 | PDE2A (0.64) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10357481-B2 | Substituted triazolo bicyclic compounds as PDE2 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-07-23 | — | — | US | disclosed |
| US-10285989-B2 | Pyrimidinone amide compounds as PDE2 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-05-14 | — | — | US | disclosed |
| US-10285989-B2 | Pyrimidinone amide compounds as PDE2 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-05-14 | — | — | US | disclosed |
| US-20180256575-A1 | PYRIMIDINONE AMIDE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-09-13 | — | — | US | disclosed |
| US-20180169072-A1 | SUBSTITUTED TRIAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME LLC | 2018-06-21 | — | — | US | disclosed |
| CN-104245698-B | Nitrogen-containing heterocyclic compound | TAKEDA PHARMACEUTICAL CO.,LTD. (JP) | 2016-11-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180169072-A1 | SUBSTITUTED TRIAZOLO BICYCLIC COMPOUNDS AS PDE2 INHIBITORS | PDE2A, PDE3A, PDE4D | PDE2A 1/4885EPHX2 704/4885SLC7A5 3022/4885 |
| US-10357481-B2 | Substituted triazolo bicyclic compounds as PDE2 inhibitors | PDE2A, PDE3A, PDE4D | PDE2A 1/4885EPHX2 704/4885SLC7A5 3022/4885 |
| US-10285989-B2 | Pyrimidinone amide compounds as PDE2 inhibitors | PDE12, PDE2A, PDE4D | PDE2A 2/4885EPHX2 1092/4885SLC7A5 2841/4885 |
| US-20180256575-A1 | PYRIMIDINONE AMIDE COMPOUNDS AS PDE2 INHIBITORS | PDE12, PDE2A, PDE4D | PDE2A 2/4885EPHX2 1092/4885SLC7A5 2841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.