Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 9/20 | 0.49 |
| ▸ | GBA1 | P04062 | 5/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20273732 | 0.91 | ABCG2 (0.51) | ABCG2GBA1ABCB1LMNACYP1A2 | |
| SCHEMBL14474516 | 0.90 | ABCG2 (0.52) | ABCG2GBA1ABCB1LMNACYP1A2 | |
| SCHEMBL14475596 | 0.90 | ABCG2 (0.52) | ABCG2GBA1ABCB1LMNACYP1A2 | |
| SCHEMBL14475218 | 0.90 | ABCG2 (0.52) | ABCG2GBA1ABCB1LMNACYP1A2 | |
| SCHEMBL14475591 | 0.83 | GBA1 (0.64) | ABCG2GBA1ABCB1LMNACYP1A2 | |
| SCHEMBL14475595 | 0.81 | GBA1 (0.64) | ABCG2GBA1ABCB1LMNACYP1A2 | |
| SCHEMBL14475115 | 0.78 | ABCG2 (0.52) | ABCG2GBA1ABCB1LMNACYP1A2 | |
| SCHEMBL14475121 | 0.76 | MAPT (0.61) | ABCG2GBA1ABCB1LMNACYP1A2 | |
| SCHEMBL2154983 | 0.76 | ABCG2 (0.65) | ABCG2ABCB1LMNACYP1A2CYP3A4 | |
| SCHEMBL14727928 | 0.75 | ABCG2 (0.62) | ABCG2GBA1ABCB1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3056207-B1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMA CO LTD (JP) | 2018-06-20 | — | — | EP | disclosed |