Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.56 |
| ▸ | TSHR | P16473 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.56 |
| ▸ | USP2 | O75604 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | GBA1 | P04062 | 4/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14475210 | 0.89 | MAPT (0.60) | MAPTABCG2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14475148 | 0.88 | GBA1 (0.62) | MAPTABCG2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14475102 | 0.87 | MAPT (0.58) | MAPTABCG2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14475553 | 0.86 | MAPT (0.64) | MAPTABCG2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14475569 | 0.86 | MAPT (0.67) | MAPTABCG2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14475598 | 0.86 | GBA1 (0.71) | MAPTABCG2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14475542 | 0.86 | MAPT (0.61) | MAPTABCG2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14727836 | 0.85 | ABCG2 (0.57) | MAPTABCG2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14727828 | 0.85 | MAPT (0.57) | MAPTABCG2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14475079 | 0.85 | MAPT (0.56) | MAPTABCG2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3056207-B1 | THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE | OTSUKA PHARMA CO LTD (JP) | 2018-06-20 | — | — | EP | disclosed |