Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.53 |
| ▸ | TACR1 | P25103 | 2/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 2/20 | 0.44 |
| ▸ | STS | P08842 | 2/20 | 0.43 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20283114 | 0.89 | PDE4B (0.53) | PDE4BTACR1RORCMC4RSTS | |
| SCHEMBL16780016 | 0.88 | PDE4B (0.57) | PDE4BTACR1RORCMC4RSTS | |
| SCHEMBL13858719 | 0.88 | PDE4B (0.57) | PDE4BTACR1RORCMC4RSTS | |
| SCHEMBL16780015 | 0.88 | PDE4B (0.57) | PDE4BTACR1RORCMC4RSTS | |
| SCHEMBL528139 | 0.84 | DPP4 (0.51) | PDE4BTACR1RORCMC4RSTS | |
| SCHEMBL4008250 | 0.80 | PDE4B (0.57) | PDE4BTACR1RORCSTSTP53 | |
| SCHEMBL14498551 | 0.80 | PDE4B (0.57) | PDE4BTACR1RORCSTSTP53 | |
| SCHEMBL14495628 | 0.80 | PDE4B (0.57) | PDE4BTACR1RORCSTSTP53 | |
| SCHEMBL20757065 | 0.80 | TP53 (0.52) | PDE4BRORCSTSTP53MAPT | |
| SCHEMBL31171241 | 0.79 | PDE4B (0.59) | PDE4BTACR1RORCMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3555065-B1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INT (DE) | 2021-02-24 | — | — | EP | disclosed |
| WO-2018111803-A1 | COMPOUNDS AS MODULATORS OF ROR GAMMA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-06-21 | — | — | WO | disclosed |