Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 13/20 | 0.61 |
| ▸ | CDK7 | P50613 | 5/20 | 0.43 |
| ▸ | CCNH | P51946 | 5/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CCNK | O75909 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.43 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18122693 | 0.93 | CSNK2A1 (0.62) | CSNK2A1CDK7CCNHMNAT1CCNT1 | |
| SCHEMBL20550095 | 0.93 | CSNK2A1 (0.62) | CSNK2A1CDK7CCNHMNAT1CCNT1 | |
| SCHEMBL21473914 | 0.89 | CSNK2A1 (0.76) | CSNK2A1CDK2CDK9CSNK2A2CSNK2B | |
| SCHEMBL21473081 | 0.89 | CDK7 (0.53) | CSNK2A1CDK7CCNHMNAT1CDK2 | |
| SCHEMBL18313623 | 0.87 | CSNK2A1 (0.56) | CSNK2A1CDK7CCNHMNAT1CCNT1 | |
| SCHEMBL20549637 | 0.86 | CSNK2A1 (0.57) | CSNK2A1CCNE1CDK2 | |
| SCHEMBL18122696 | 0.86 | CSNK2A1 (0.57) | CSNK2A1CCNE1CDK2 | |
| SCHEMBL20286068 | 0.85 | CDK2 (0.50) | CSNK2A1CDK7CCNHMNAT1CCNT1 | |
| SCHEMBL20288878 | 0.84 | CSNK2A1 (0.68) | CSNK2A1CDK2CDK9CSNK2A2CSNK2B | |
| SCHEMBL20549447 | 0.82 | CDK7 (0.57) | CSNK2A1CDK7CCNHMNAT1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183240-A9 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-06-15 | — | — | US | disclosed |
| US-20180169097-A1 | COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180169097-A1 | COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS | CHUK, BCOR, MYC | CSNK2A1 145/4885CDK7 130/4885CCNH 539/4885 |
| US-20230183240-A9 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | CDK3, CDK13, CDK1 | CSNK2A1 403/4885CDK7 12/4885CCNH 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.