Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 18/20 | 0.63 |
| ▸ | IDH2 | P48735 | 13/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29765335 | 0.90 | IDH1 (0.78) | IDH1IDH2 | |
| SCHEMBL22572276 | 0.90 | IDH1 (0.78) | IDH1IDH2 | |
| SCHEMBL20289358 | 0.90 | IDH1 (0.78) | IDH1IDH2 | |
| SCHEMBL22879045 | 0.88 | IDH1 (0.81) | IDH1IDH2 | |
| SCHEMBL22879042 | 0.84 | IDH1 (0.60) | IDH1IDH2 | |
| SCHEMBL20289762 | 0.82 | IDH1 (0.65) | IDH1IDH2 | |
| SCHEMBL23343374 | 0.79 | IDH1 (0.84) | IDH1IDH2 | |
| SCHEMBL20270243 | 0.79 | IDH1 (0.84) | IDH1IDH2 | |
| SCHEMBL20270245 | 0.79 | IDH1 (0.84) | IDH1IDH2 | |
| SCHEMBL30274604 | 0.79 | IDH1 (0.77) | IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3763717-B1 | PYRIDO[4,3-D][1,3]OXAZIN-2-ONE COMPOUNDS AS MUTANT IDH1 AND IDH2 INHIBITORS | LILLY CO ELI (US) | 2023-03-08 | — | — | EP | disclosed |
| EP-3763717-A1 | PYRIDO[4,3-D][1,3]OXAZIN-2-ONE AND PYRIMIDO[4,5-D][1,3]OXAZIN-2-ONE COMPOUNDS AS MUTANT IDH1 AND IDH2 INHIBITORS | ELI LILLY AND CO. (US) | 2021-01-13 | — | — | EP | disclosed |
| EP-3555105-B1 | 7-PHENYLETHYLAMINO-4H-PYRIMIDO[4,5-D][1,3]OXAZIN-2-ONE COMPOUNDS AS MUTANT IDH1 AND IDH2 INHIBITORS | LILLY CO ELI (US) | 2020-10-28 | — | — | EP | disclosed |
| WO-2018111707-A1 | 7-PHENYLETHYLAMINO-4H-PYRIMIDO[4,5-D][1,3]OXAZIN-2-ONE COMPOUNDS AS MUTANT IDH1 AND IDH2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2018-06-21 | — | — | WO | disclosed |