Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.71 |
| ▸ | BRD2 | P25440 | 4/20 | 0.70 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.70 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.70 |
| ▸ | TERT | O14746 | 4/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.55 |
| ▸ | IL17A | Q16552 | 1/20 | 0.54 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20291212 | 0.99 | BRD4 (0.72) | BRD4BRD2BRD3BRDTTERT | |
| SCHEMBL20291065 | 0.93 | BRD4 (0.73) | BRD4BRD2BRD3BRDTTERT | |
| SCHEMBL20291215 | 0.93 | BRD4 (0.69) | BRD4BRD2BRD3BRDTTERT | |
| SCHEMBL20291417 | 0.90 | BRD4 (0.66) | BRD4BRD2BRD3BRDTTERT | |
| SCHEMBL20291211 | 0.89 | BRD4 (0.67) | BRD4BRD2BRD3BRDTTERT | |
| SCHEMBL30599697 | 0.84 | BRD4 (1.00) | BRD4BRD2BRD3BRDTABCB1 | |
| SCHEMBL20271941 | 0.84 | BRD4 (1.00) | BRD4BRD2BRD3BRDTABCB1 | |
| SCHEMBL23787087 | 0.83 | BRD4 (1.00) | BRD4BRD2BRD3BRDTTERT | |
| SCHEMBL20271946 | 0.83 | BRD4 (1.00) | BRD4BRD2BRD3BRDTTERT | |
| SCHEMBL20291077 | 0.83 | BRD4 (1.00) | BRD4BRD2BRD3BRDTTERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3554503-B1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | UNIV TEXAS (US) | 2023-10-04 | — | — | EP | disclosed |
| WO-2018112037-A1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | ZHOU JIA (US) | 2018-06-21 | — | — | WO | disclosed |