Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 1/20 | 0.75 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.67 |
| ▸ | CLK1 | P49759 | 8/20 | 0.67 |
| ▸ | KIF20A | O95235 | 6/20 | 0.67 |
| ▸ | CLK2 | P49760 | 2/20 | 0.67 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.67 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.67 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.67 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.67 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.59 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.51 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.51 |
| ▸ | NEK2 | P51955 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18301172 | 0.86 | PIP4K2A (1.00) | PIP4K2ADYRK1ACLK1KIF20ACLK2 | |
| SCHEMBL18301135 | 0.86 | PIP4K2A (1.00) | PIP4K2ADYRK1ACLK1KIF20ACLK2 | |
| SCHEMBL20293914 | 0.83 | PIP4K2A (0.72) | PIP4K2ADYRK1ACLK1KIF20ACLK2 | |
| SCHEMBL20293909 | 0.83 | PIP4K2A (0.72) | PIP4K2ADYRK1ACLK1KIF20ACLK2 | |
| SCHEMBL18301145 | 0.83 | PIP4K2A (0.72) | PIP4K2ADYRK1ACLK1KIF20ACLK2 | |
| SCHEMBL20293906 | 0.83 | PIP4K2A (0.72) | PIP4K2ADYRK1ACLK1KIF20ACLK2 | |
| SCHEMBL18301144 | 0.83 | PIP4K2A (0.72) | PIP4K2ADYRK1ACLK1KIF20ACLK2 | |
| SCHEMBL18301136 | 0.81 | DYRK1A (0.70) | PIP4K2ADYRK1ACLK1KIF20ACLK2 | |
| SCHEMBL18301137 | 0.81 | DYRK1A (0.70) | PIP4K2ADYRK1ACLK1KIF20ACLK2 | |
| SCHEMBL13035549 | 0.80 | DYRK1A (1.00) | PIP4K2ADYRK1ACLK1KIF20ACLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307724-B1 | (Z)-2-(1H-INDOL-3-YL)-3-(ISOQUINOLIN-5-YL)ACRYLONITRILE DERIVATIVES AND RELATED COMPOUNDS WITH LYSOSOME INHIBITORY AND ANTI-MITOTIC ACTIVITY FOR TREATING HYPERPROLIFERATIVE DISEASES | NAT UNIV SINGAPORE (SG) | 2020-06-10 | — | — | EP | disclosed |
| US-20190350964-A1 | ANTI-CANCER COMPOUNDS AND USES THEREOF | NAT UNIV SINGAPORE (SG) | 2019-11-21 | — | — | US | disclosed |
| US-10308631-B2 | Selective anti-cancer compounds | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2019-06-04 | — | — | US | disclosed |
| US-20180179178-A1 | SELECTIVE ANTI-CANCER COMPOUNDS | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2018-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10308631-B2 | Selective anti-cancer compounds | CCNA1, CCNY, CCNT1 | PIP4K2A 2352/4885DYRK1A 1879/4885CLK1 1998/4885 |
| US-20180179178-A1 | SELECTIVE ANTI-CANCER COMPOUNDS | CCNA1, CCNY, CCNT1 | PIP4K2A 2352/4885DYRK1A 1879/4885CLK1 1998/4885 |
| US-20190350964-A1 | ANTI-CANCER COMPOUNDS AND USES THEREOF | PIK3CD, PIK3CA, PI4KB | PIP4K2A 22/4885DYRK1A 3263/4885CLK1 734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.