Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.54 |
| ▸ | CDC7 | O00311 | 2/20 | 0.53 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
| ▸ | SCD | O00767 | 4/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20298708 | 0.80 | BTK (0.52) | BTKCDC7DBF4CCNE1CDK2 | |
| SCHEMBL2488956 | 0.79 | CDC7 (0.64) | CDC7DBF4CCNE1CDK2PARP1 | |
| SCHEMBL4767842 | 0.70 | BTK (1.00) | BTKSCN9A | |
| SCHEMBL27857887 | 0.70 | CDC7 (0.53) | CDC7DBF4CCNE1CDK2L3MBTL1 | |
| SCHEMBL11957358 | 0.69 | BTK (0.98) | BTKSCN9A | |
| SCHEMBL8823085 | 0.68 | BTK (0.48) | BTKCDC7DBF4ALDH1A1 | |
| SCHEMBL952856 | 0.66 | CDC7 (0.54) | CDC7DBF4CCNE1CDK2PARP1 | |
| SCHEMBL21820809 | 0.66 | MEN1 (0.48) | BTKCCNE1CDK2ALDH1A1 | |
| SCHEMBL17766752 | 0.66 | TRPV1 (0.53) | BTK | |
| SCHEMBL12153768 | 0.65 | BTK (0.67) | BTKLIMK1ALDH1A1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558956-A1 | N-CYCLOBUTYL-THIAZOL-5-CARBOXAMIDES WITH NEMATICIDAL ACTIVITY | Syngenta Participations AG (CH) | 2019-10-30 | — | — | EP | disclosed |
| WO-2018114657-A1 | N-CYCLOBUTYL-THIAZOL-5-CARBOXAMIDES WITH NEMATICIDAL ACTIVITY | SYNGENTA PARTICIPATIONS AG (CH) | 2018-06-28 | — | — | WO | disclosed |