Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ivabradine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 known ✓ | Q9Y3Q4 | 3/20 | 0.96 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.96 |
| ▸ | HTR1A | P08908 | 1/20 | 0.96 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.96 |
| ▸ | DRD3 | P35462 | 1/20 | 0.96 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KCNN2 | Q9H2S1 | 4/20 | 0.39 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.39 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ivabradine SCHEMBL29465192 | 0.99 | HCN4 (0.98) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| Ivabradine SCHEMBL23470 | 0.99 | HCN4 (0.98) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| Ivabradine SCHEMBL26678166 | 0.99 | HCN4 (0.98) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| Ivabradine SCHEMBL29561458 | 0.99 | HCN4 (0.98) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| Ivabradine SCHEMBL2821678 | 0.99 | HCN4 (0.98) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| Ivabradine SCHEMBL1034220 | 0.98 | HCN4 (0.96) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| Ivabradine SCHEMBL333201 | 0.98 | HCN4 (1.00) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| Ivabradine SCHEMBL23472 | 0.98 | HCN4 (1.00) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| Ivabradine SCHEMBL5163239 | 0.98 | HCN4 (1.00) | HCN4CHRM2HTR1ASLC6A4DRD3 | |
| Ivabradine SCHEMBL29387763 | 0.98 | HCN4 (1.00) | HCN4CHRM2HTR1ASLC6A4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558948-A1 | NEW SALT OF IVABRADINE AND USES THEREOF | Biogena (A.P.I) Ltd (CY) | 2019-10-30 | — | — | EP | disclosed |
| WO-2018115181-A1 | NEW SALT OF IVABRADINE AND USES THEREOF | Biogena (A.P.I) Ltd (CY) | 2018-06-28 | — | — | WO | disclosed |