Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | PREP | P48147 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15700445 | 0.84 | CHRM2 (0.47) | CHRM2CHRM1CHRM3PREPHPGD | |
| SCHEMBL16338682 | 0.84 | CHRM2 (0.47) | CHRM2CHRM1CHRM3PREPHPGD | |
| SCHEMBL15188280 | 0.84 | CHRM2 (0.47) | CHRM2CHRM1CHRM3PREPHPGD | |
| SCHEMBL756839 | 0.84 | CHRM2 (0.47) | CHRM2CHRM1CHRM3PREPHPGD | |
| SCHEMBL13096648 | 0.84 | CHRM2 (0.47) | CHRM2CHRM1CHRM3PREPHPGD | |
| SCHEMBL9885648 | 0.84 | CHRM2 (0.47) | CHRM2CHRM1CHRM3PREPHPGD | |
| SCHEMBL18901834 | 0.80 | CHRM2 (0.45) | CHRM2CHRM1CHRM3PREPHPGD | |
| SCHEMBL18901924 | 0.80 | CHRM2 (0.45) | CHRM2CHRM1CHRM3PREPHPGD | |
| SCHEMBL29102351 | 0.80 | CHRM2 (0.45) | CHRM2CHRM1CHRM3PREPHPGD | |
| SCHEMBL26782299 | 0.80 | CHRM2 (0.45) | CHRM2CHRM1CHRM3PREPHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3406252-B1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS INC (US) | 2020-05-13 | — | — | EP | disclosed |
| EP-2812004-B1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS INC (US) | 2018-06-27 | — | — | EP | disclosed |