Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Evacetrapib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP known ✓ | P11597 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Evacetrapib SCHEMBL20780398 | 1.00 | CETP (1.00) | CETP | |
| Evacetrapib SCHEMBL108602 | 1.00 | CETP (1.00) | CETP | |
| Evacetrapib SCHEMBL108367 | 1.00 | CETP (1.00) | CETP | |
| Evacetrapib SCHEMBL141340 | 1.00 | CETP (1.00) | CETP | |
| Evacetrapib SCHEMBL145131 | 0.99 | CETP (0.99) | CETP | |
| Evacetrapib SCHEMBL141258 | 0.99 | CETP (0.99) | CETP | |
| Evacetrapib SCHEMBL141256 | 0.99 | CETP (0.99) | CETP | |
| Evacetrapib SCHEMBL139419 | 0.99 | CETP (0.99) | CETP | |
| Evacetrapib SCHEMBL145129 | 0.99 | CETP (0.99) | CETP | |
| Evacetrapib SCHEMBL139421 | 0.99 | CETP (0.99) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795695-A1 | GENETIC MARKERS FOR PREDICTING RESPONSIVENESS TO THERAPY | F. Hoffmann-La Roche AG (CH) | 2021-03-24 | — | — | EP | disclosed |
| EP-3174995-B1 | GENETIC MARKERS FOR PREDICTING RESPONSIVENESS TO THERAPY WITH HDL-RAISING OR HDL MIMICKING AGENT | HOFFMANN LA ROCHE (CH) | 2020-08-19 | — | — | EP | disclosed |
| EP-2978859-B1 | GENETIC MARKERS FOR PREDICTING RESPONSIVENESS TO THERAPY | HOFFMANN LA ROCHE (CH) | 2018-06-27 | — | — | EP | disclosed |