Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 7/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29812811 | 0.83 | PDCD1 (0.54) | MAPK8PDCD1CD274 | |
| SCHEMBL20293591 | 0.83 | PDCD1 (0.54) | MAPK8PDCD1CD274 | |
| SCHEMBL30661741 | 0.80 | PDCD1 (0.48) | MAPK8PDCD1CD274 | |
| SCHEMBL30661742 | 0.80 | PDCD1 (0.48) | MAPK8PDCD1CD274 | |
| SCHEMBL30522688 | 0.78 | PARP1 (0.39) | PARP1TNKS2PARP2ESR2GRAMD1A | |
| SCHEMBL24722368 | 0.77 | PARP1 (0.43) | PARP1TNKS2PARP2MAPK8ESR2 | |
| SCHEMBL30145362 | 0.76 | PDCD1 (0.53) | PARP1TNKS2PARP2MAPK8PDCD1 | |
| SCHEMBL20293195 | 0.76 | PDCD1 (0.53) | PARP1TNKS2PARP2MAPK8PDCD1 | |
| SCHEMBL20295572 | 0.75 | PDCD1 (0.48) | MAPK8PDCD1CD274BACE1 | |
| SCHEMBL30740265 | 0.75 | PDCD1 (0.48) | MAPK8PDCD1CD274BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4223369-A1 | IMMUNOMODULATOR COMPOUNDS AND METHODS OF USE | Incyte Corporation (US) | 2023-08-09 | — | — | EP | disclosed |
| WO-2018119224-A1 | TETRAHYDRO IMIDAZO[4,5-C]PYRIDINE DERIVATIVES AS PD-L1 INTERNALIZATION INDUCERS | INCYTE CORPORATION (US) | 2018-06-28 | — | — | WO | disclosed |