Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25588383 | 0.83 | DYRK1A (0.50) | PIK3CAKDRRETRIPK2MAPK14 | |
| SCHEMBL20319074 | 0.77 | DYRK1A (0.58) | PIK3CADYRK1ADYRK1BCDK9NUDT1 | |
| SCHEMBL15344926 | 0.75 | ELANE (0.50) | KDRCYP2A6ELANECYP3A4CYP2D6 | |
| SCHEMBL20292913 | 0.73 | PTPN11 (0.49) | PIK3CAKDRRETRIPK2MAPK14 | |
| SCHEMBL20318999 | 0.72 | PIK3CA (0.53) | PIK3CAKDRRETRIPK2MAPK14 | |
| SCHEMBL20292770 | 0.71 | PTPN11 (0.51) | PIK3CAKDRRETRIPK2MAPK14 | |
| SCHEMBL20319801 | 0.71 | DYRK1A (0.47) | PIK3CAKDRRETRIPK2MAPK14 | |
| SCHEMBL729449 | 0.70 | PIK3CA (1.00) | PIK3CAKDRRETRIPK2MAPK14 | |
| SCHEMBL15452489 | 0.69 | CYP2A6 (0.54) | PIK3CACYP2A6ELANEPIK3C3CYP1A2 | |
| SCHEMBL20292748 | 0.68 | DYRK1B (0.68) | PIK3CACLK4DYRK1ADYRK1BMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119039-A1 | DERIVATIVES OF QUINOLINES AS INHIBITORS OF DYRK1A AND/OR DYRK1B KINASES | FELICITEX THERAPEUTICS, INC. (US) | 2018-06-28 | — | — | WO | disclosed |