Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15510820 | 0.84 | TSHR (0.40) | TSHRALDH1A1 | |
| SCHEMBL18859435 | 0.83 | HTR1B (0.34) | TSHRALDH1A1 | |
| SCHEMBL8979951 | 0.79 | TSHR (0.48) | TSHRKDM4ERECQLALDH1A1 | |
| SCHEMBL20314556 | 0.78 | CYP4F2 (0.35) | TSHRCYP4F2CYP4A11 | |
| SCHEMBL20314555 | 0.78 | CYP4F2 (0.35) | TSHRCYP4F2CYP4A11 | |
| SCHEMBL20314559 | 0.78 | CYP4F2 (0.35) | TSHRCYP4F2CYP4A11 | |
| SCHEMBL13668379 | 0.78 | TSHR (0.40) | TSHRKDM4ERECQLALDH1A1 | |
| SCHEMBL23945494 | 0.77 | TSHR (0.50) | TSHRKDM4ERECQLALDH1A1 | |
| SCHEMBL22473702 | 0.77 | TSHR (0.50) | TSHRKDM4ERECQLALDH1A1 | |
| SCHEMBL22837699 | 0.77 | TSHR (0.48) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119448-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | Arvinas, Inc. (US) | 2018-06-28 | — | — | WO | disclosed |