Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | GCK | P35557 | 6/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21982871 | 1.00 | CYP4F2 (0.37) | CYP4F2CYP4A11GCKFFAR4MTNR1A | |
| SCHEMBL18592300 | 0.92 | CYP4F2 (0.38) | CYP4F2CYP4A11GCKFFAR4MTNR1A | |
| SCHEMBL22560664 | 0.92 | CYP4F2 (0.38) | CYP4F2CYP4A11GCKFFAR4MTNR1A | |
| SCHEMBL18592294 | 0.92 | CYP4F2 (0.38) | CYP4F2CYP4A11GCKFFAR4MTNR1A | |
| SCHEMBL20046556 | 0.89 | IAPP (0.35) | CYP4F2CYP4A11GCKFFAR4MTNR1A | |
| SCHEMBL20443669 | 0.89 | IAPP (0.35) | CYP4F2CYP4A11GCKFFAR4MTNR1A | |
| SCHEMBL20133413 | 0.88 | CYP4F2 (0.39) | CYP4F2CYP4A11GCKFFAR4MTNR1A | |
| SCHEMBL26030360 | 0.88 | CYP4F2 (0.39) | CYP4F2CYP4A11GCKFFAR4MTNR1A | |
| SCHEMBL21472028 | 0.87 | CYP4F2 (0.38) | CYP4F2CYP4A11GCKFFAR4MTNR1A | |
| SCHEMBL20443306 | 0.87 | CYP4F2 (0.38) | CYP4F2CYP4A11GCKFFAR4MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10723717-B2 | Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides | ARVINAS OPERATIONS, INC. (US) | 2020-07-28 | — | — | US | disclosed |
| US-20180179183-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | ARVINAS OPERATIONS, INC. | 2018-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180179183-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | CRBN, ARAF, VHL | CYP4F2 2758/4885CYP4A11 4432/4885GCK 4318/4885 |
| US-10723717-B2 | Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides | CRBN, ARAF, VHL | CYP4F2 2758/4885CYP4A11 4432/4885GCK 4318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.