Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.54 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.54 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.54 |
| ▸ | NT5E | P21589 | 1/20 | 0.54 |
| ▸ | TGM2 | P21980 | 1/20 | 0.53 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.49 |
| ▸ | KRAS | P01116 | 9/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.47 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20325346 | 1.00 | POLB (0.64) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL9856344 | 0.94 | POLB (0.67) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL21132941 | 0.94 | POLB (0.67) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL20324606 | 0.94 | POLB (0.67) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL23679761 | 0.90 | POLB (0.78) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL29327116 | 0.90 | POLB (0.78) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL22524036 | 0.90 | POLB (0.63) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL20327203 | 0.90 | POLB (0.63) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL9856605 | 0.90 | POLB (0.67) | POLBP2RY2P2RY4P2RY6NT5E | |
| SCHEMBL22524067 | 0.89 | POLB (0.64) | POLBP2RY2P2RY4P2RY6NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020205323-A1 | STABLE FORMULATIONS OF CYCLIC DINUCLEOTIDE STING AGONIST COMPOUNDS AND METHODS OF USE THEREOF | MERCK SHARP & DOHME CORP. (US) | 2020-10-08 | — | — | WO | disclosed |
| WO-2018118664-A1 | COMBINATIONS OF PD-1 ANTAGONISTS AND CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |
| WO-2018118665-A1 | CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |