Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.30 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
| ▸ | PCNA | P12004 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | APOL1 | O14791 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18551622 | 0.91 | CYP4F2 (0.38) | EPHX2CYP4F2CYP4A11OPRM1OPRK1 | |
| SCHEMBL18611784 | 0.91 | CYP4F2 (0.38) | EPHX2CYP4F2CYP4A11OPRM1OPRK1 | |
| SCHEMBL22297391 | 0.91 | CYP4F2 (0.38) | EPHX2CYP4F2CYP4A11OPRM1OPRK1 | |
| SCHEMBL20324957 | 0.90 | EPHX2 (0.35) | EPHX2CYP4F2CYP4A11OPRM1OPRK1 | |
| SCHEMBL20443465 | 0.88 | CYP4F2 (0.36) | EPHX2CYP4F2CYP4A11OPRM1OPRK1 | |
| SCHEMBL21898997 | 0.88 | EPHX2 (0.36) | EPHX2CYP4F2CYP4A11OPRM1OPRK1 | |
| SCHEMBL20234839 | 0.88 | CYP4F2 (0.36) | EPHX2CYP4F2CYP4A11OPRM1OPRK1 | |
| SCHEMBL21899517 | 0.86 | EPHX2 (0.33) | EPHX2CYP4F2CYP4A11OPRM1OPRK1 | |
| SCHEMBL20442680 | 0.84 | SLC6A2 (0.33) | EPHX2CYP4F2CYP4A11OPRM1OPRK1 | |
| SCHEMBL22150460 | 0.81 | SLC6A2 (0.35) | EPHX2CYP4F2CYP4A11OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018140809-A1 | MODULATORS OF ESTROGEN RECEPTOR PROTEOLYSIS AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2018-08-02 | — | — | WO | disclosed |
| WO-2018119441-A1 | EGFR PROTEOLYSIS TARGETING CHIMERIC MOLECULES AND ASSOCIATED METHODS OF USE | Arvinas, Inc. (US) | 2018-06-28 | — | — | WO | disclosed |
| WO-2018119357-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ENHANCER OF ZESTE HOMOLOG 2 POLYPEPTIDE | Arvinas, Inc. (US) | 2018-06-28 | — | — | WO | disclosed |