Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.87 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.87 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.87 |
| ▸ | CNR2 | P34972 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | ACACB | O00763 | 10/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20328202 | 0.94 | CACNA1I (0.87) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL8233861 | 0.93 | CACNA1I (1.00) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL23327963 | 0.93 | CACNA1I (1.00) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL29363972 | 0.93 | CACNA1I (1.00) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL20328205 | 0.92 | CACNA1I (0.84) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL20328409 | 0.91 | CACNA1I (0.85) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL1064013 | 0.86 | CACNA1I (0.76) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL29110007 | 0.85 | CACNA1I (0.72) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL2139411 | 0.83 | CACNA1I (0.82) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 | |
| SCHEMBL2136762 | 0.83 | CACNA1I (0.82) | CACNA1ICACNA1GCACNA1HCNR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018118101-A1 | T-TYPE CALCIUM CHANNEL MODULATORS AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2018-06-28 | — | — | WO | disclosed |