Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 9/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.34 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | WHR1 | P49842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21252287 | 0.92 | PDE1B (0.37) | FGFR1FGFR2PDE1BPDE1CCCNT1 | |
| SCHEMBL20331929 | 0.89 | FGFR4 (0.37) | FGFR1FGFR2FGFR4FGFR3CCNT1 | |
| SCHEMBL20330792 | 0.86 | PDE1B (0.37) | PDE1BPDE1CCCNT1CCNKCDK9 | |
| SCHEMBL20331655 | 0.85 | CCNT1 (0.37) | FGFR1FGFR2FGFR4FGFR3CCNT1 | |
| SCHEMBL20331835 | 0.83 | WHR1 (0.36) | FGFR1FGFR2PDE1BPDE1CFGFR4 | |
| SCHEMBL20330785 | 0.83 | CCNT1 (0.36) | PDE1BPDE1CCCNT1PDCD1CD274 | |
| SCHEMBL29578546 | 0.81 | FGFR4 (0.53) | FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21240322 | 0.81 | FGFR4 (0.53) | FGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL21240085 | 0.81 | FGFR2 (0.38) | FGFR1FGFR2FGFR3WHR1 | |
| SCHEMBL29577369 | 0.81 | FGFR2 (0.38) | FGFR1FGFR2FGFR3WHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |
| WO-2018113584-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2018-06-28 | — | — | WO | disclosed |