Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 15/20 | 0.72 |
| ▸ | FGFR4 | P22455 | 12/20 | 0.65 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.65 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CSF1R | P07333 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21240421 | 0.96 | FGFR1 (0.75) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL29577552 | 0.96 | FGFR1 (0.75) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL21252405 | 0.94 | FGFR1 (0.71) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL15413160 | 0.84 | FGFR1 (1.00) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL20331505 | 0.84 | FGFR1 (0.68) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL29577933 | 0.84 | FGFR1 (0.68) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL15434010 | 0.83 | FGFR1 (1.00) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL15412800 | 0.82 | FGFR1 (0.78) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL20331116 | 0.82 | FGFR1 (0.77) | FGFR1FGFR4FGFR2FGFR3CYP1A2 | |
| SCHEMBL30045140 | 0.82 | FGFR1 (0.77) | FGFR1FGFR4FGFR2FGFR3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018113584-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2018-06-28 | — | — | WO | disclosed |