Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28245182 | 1.00 | CHEK1 (0.46) | CHEK1CCNA2CDK2CCNA1CCNT1 | |
| SCHEMBL28063327 | 0.90 | HRH3 (0.42) | CHEK1CCNA2CDK2CCNA1CCNT1 | |
| SCHEMBL30260114 | 0.81 | FEN1 (0.39) | KCNH2 | |
| SCHEMBL1221900 | 0.81 | FEN1 (0.39) | KCNH2 | |
| SCHEMBL1831010 | 0.81 | BACE1 (0.41) | KCNH2 | |
| SCHEMBL15587840 | 0.81 | MAP3K12 (0.43) | CHEK1CCNA2CDK2CCNA1MAPK8 | |
| SCHEMBL2034798 | 0.80 | CHEK1 (0.47) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL3567520 | 0.80 | MKNK1 (0.44) | CCNT1CDK9ROCK1 | |
| SCHEMBL23667387 | 0.80 | BACE1 (0.44) | KCNH2 | |
| Hydrochloric Acid SCHEMBL20292168 | 0.79 | MKNK1 (0.43) | CCNT1CDK9ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133657-A1 | PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA | SAVIRA PHARMACEUTICALS GMBH (AT) | 2017-08-10 | — | — | WO | disclosed |
| EP-2516436-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2012-10-31 | — | — | EP | disclosed |
| WO-2011076419-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-06-30 | — | — | WO | disclosed |