Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.53 |
| ▸ | TTK | P33981 | 1/20 | 0.52 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2030679 | 0.94 | ALK (0.58) | LRRK2PTK2ALKTTK | |
| SCHEMBL2029362 | 0.89 | PTK2 (0.56) | LRRK2PTK2ALKMAPK3 | |
| SCHEMBL2031292 | 0.89 | PTK2 (0.66) | LRRK2PTK2ALK | |
| SCHEMBL2033479 | 0.88 | ALK (0.57) | LRRK2PTK2ALKMAPK3 | |
| SCHEMBL2033915 | 0.88 | PTK2 (0.57) | LRRK2PTK2ALKMAPK3 | |
| SCHEMBL2032374 | 0.88 | PTK2 (0.55) | LRRK2PTK2ALK | |
| SCHEMBL2054041 | 0.87 | PTK2 (0.53) | PTK2 | |
| SCHEMBL2637530 | 0.87 | LRRK2 (0.60) | LRRK2PTK2ALKTTKMAPK3 | |
| SCHEMBL2052382 | 0.86 | LRRK2 (0.52) | LRRK2ALKTTK | |
| SCHEMBL2033403 | 0.84 | LRRK2 (0.57) | LRRK2PTK2ALKTTKMAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399433-B2 | Amino pyrimidine anticancer compounds | OSI Pharmaceuticals, LLC (US) | 2013-03-19 | — | — | US | disclosed |
| US-20110136764-A1 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136764-A1 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | DPYD, PTK2, TYMS | LRRK2 854/4885PTK2 2/4885ALK 872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.