Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.68 |
| ▸ | BRD4 | O60885 | 2/20 | 0.68 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20317425 | 0.92 | EZH2 (0.65) | EZH2BRD4 | |
| SCHEMBL15490871 | 0.87 | EZH2 (0.70) | EZH2EZH1 | |
| SCHEMBL12180071 | 0.87 | EZH2 (0.65) | EZH2BRD4EZH1 | |
| SCHEMBL2594805 | 0.87 | EZH2 (0.65) | EZH2BRD4EZH1 | |
| SCHEMBL2588878 | 0.85 | EZH2 (0.67) | EZH2BRD4EZH1 | |
| SCHEMBL14717619 | 0.84 | EZH2 (0.62) | EZH2BRD4EZH1 | |
| SCHEMBL28795470 | 0.82 | EZH2 (1.00) | EZH2BRD4EZH1 | |
| SCHEMBL17584935 | 0.81 | EZH2 (0.57) | EZH2BRD4 | |
| SCHEMBL2592259 | 0.81 | EZH2 (0.67) | EZH2EZH1 | |
| SCHEMBL12498496 | 0.80 | EZH2 (0.66) | EZH2EZH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119357-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ENHANCER OF ZESTE HOMOLOG 2 POLYPEPTIDE | Arvinas, Inc. (US) | 2018-06-28 | — | — | WO | disclosed |