Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 7/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.32 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28602188 | 1.00 | TSHR (0.43) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Bromide SCHEMBL2034062 | 1.00 | TSHR (0.43) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Bromide SCHEMBL2775333 | 1.00 | TSHR (0.43) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Bromide SCHEMBL8422831 | 0.96 | TSHR (0.40) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Bromide SCHEMBL10868159 | 0.96 | TSHR (0.40) | TSHRLMNATHRBDNM1ALDH1A1 | |
| SCHEMBL6033 | 0.96 | TSHR (0.46) | TSHRLMNATHRBDNM1ALDH1A1 | |
| SCHEMBL7874985 | 0.96 | TSHR (0.46) | TSHRLMNATHRBDNM1ALDH1A1 | |
| SCHEMBL821221 | 0.96 | TSHR (0.46) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Bromide SCHEMBL9574838 | 0.93 | TSHR (0.53) | TSHRLMNATHRBDNM1ALDH1A1 | |
| Tridecane SCHEMBL9574845 | 0.93 | TSHR (0.53) | TSHRLMNATHRBDNM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113117523-B | Forward osmosis extraction material, preparation method thereof and forward osmosis water desalination system using forward osmosis extraction material | 财团法人工业技术研究院 | 2023-02-03 | — | — | CN | disclosed |
| CN-113117523-A | Forward osmosis extraction material, preparation method thereof and forward osmosis water desalination system using forward osmosis extraction material | 财团法人工业技术研究院 | 2021-07-16 | — | — | CN | disclosed |
| CN-108976258-B | Multi-branched cationic phosphonium salt, forward osmosis extract containing same, and forward osmosis seawater desalination process | 财团法人工业技术研究院 | 2021-04-20 | — | — | CN | disclosed |
| WO-2011070419-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF DARIFENACIN HYDROBROMIDE | AUROBINDO PHARMA LIMITED (IN) | 2011-06-16 | — | — | WO | disclosed |
| EP-1618095-A2 | PREPARATION OF SUBSTITUTED QUINAZOLINES | Warner-Lambert Company LLC (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004069791-A2 | PREPARATION OF SUBSTITUTED QUINAZOLINES | WARNER-LAMBERT COMPANY LLC (US) | 2004-08-19 | — | — | WO | disclosed |
| US-20040158065-A1 | Preparation of substituted quinazolines | BARTH HUBERT (DE) | 2004-08-12 | — | — | US | disclosed |
| US-4366102-A | Process for the preparation of chloroformic acid aryl esters | BAYER AKTIENGESELLSCHAFT (DE) | 1982-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040158065-A1 | Preparation of substituted quinazolines | RAF1, CDKN1A, MAP3K1 | TSHR 3528/4885LMNA 2564/4885THRB 3501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.