Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28917614 | 0.88 | KMT2A (0.54) | CYP1A2CYP2C19HSD17B10TSHRKMT2A | |
| SCHEMBL19224500 | 0.85 | CYP1A2 (0.51) | CYP1A2CYP2C19HSD17B10TSHRKMT2A | |
| SCHEMBL15956522 | 0.84 | MAPT (0.52) | CYP1A2CYP2C19TSHRKMT2ARAB9A | |
| SCHEMBL17321302 | 0.82 | KMT2A (0.50) | TSHRKMT2ARAB9AMEN1MAPT | |
| SCHEMBL25176595 | 0.80 | HCAR2 (0.55) | CYP1A2CYP2C19HSD17B10MAPTALDH1A1 | |
| SCHEMBL15452628 | 0.79 | KMT2A (0.50) | CYP2C19HSD17B10TSHRKMT2ARAB9A | |
| SCHEMBL22644138 | 0.77 | MAPT (0.61) | KMT2ARAB9AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL11823771 | 0.77 | HCAR2 (0.61) | TSHRKMT2ARAB9AMEN1MAPT | |
| SCHEMBL69157 | 0.74 | MAPT (0.72) | CYP1A2CYP2C19HSD17B10KMT2ARAB9A | |
| SCHEMBL31485417 | 0.74 | SMN1; SMN2 (0.53) | CYP1A2CYP2C19HSD17B10RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |