Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.53 |
| ▸ | CD63 | P08962 | 2/20 | 0.53 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | CCR4 | P51679 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15552545 | 0.85 | SYK (0.71) | SYKCD63AURKAJAK2 | |
| SCHEMBL15552542 | 0.85 | SYK (0.71) | SYKCD63AURKAJAK2 | |
| SCHEMBL16848689 | 0.85 | SYK (0.71) | SYKCD63AURKAJAK2 | |
| SCHEMBL15552238 | 0.78 | SYK (0.62) | SYKCD63AURKAJAK2 | |
| SCHEMBL15552562 | 0.76 | SYK (0.66) | SYKCD63AURKAJAK2 | |
| SCHEMBL15552563 | 0.76 | SYK (0.66) | SYKCD63AURKAJAK2 | |
| SCHEMBL15552276 | 0.73 | SYK (0.53) | SYKCD63AURKAJAK2 | |
| SCHEMBL15552279 | 0.73 | SYK (0.53) | SYKCD63AURKAJAK2 | |
| SCHEMBL16820600 | 0.71 | SYK (0.78) | SYKCD63AURKAJAK2 | |
| SCHEMBL16820596 | 0.71 | SYK (0.78) | SYKCD63AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342773-A1 | SYK INHIBITORS | Gilead Sciences, Inc. (US) | 2018-07-04 | — | — | EP | disclosed |