Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20347094 | 0.90 | PTPN11 (0.49) | PTPN11KCNH2 | |
| SCHEMBL20347113 | 0.90 | PTPN11 (0.59) | PTPN11KCNH2 | |
| SCHEMBL18328378 | 0.89 | PTPN11 (0.66) | PTPN11KCNH2 | |
| SCHEMBL20347102 | 0.89 | PTPN11 (0.57) | PTPN11KCNH2 | |
| SCHEMBL20347117 | 0.83 | PTPN11 (0.52) | PTPN11KCNH2 | |
| SCHEMBL21926707 | 0.83 | PTPN11 (0.53) | PTPN11KCNH2 | |
| SCHEMBL20347114 | 0.82 | PTPN11 (0.49) | PTPN11KCNH2 | |
| SCHEMBL20347093 | 0.82 | PTPN11 (0.56) | PTPN11KCNH2 | |
| SCHEMBL20347127 | 0.82 | PTPN11 (0.59) | PTPN11KCNH2 | |
| SCHEMBL20347091 | 0.81 | PTPN11 (0.50) | PTPN11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180186770-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. | 2018-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180186770-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 | PTPN1, PTPN3, PTPN2 | PTPN11 12/4885KCNH2 3266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.