Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.77 |
| ▸ | PARP2 | Q9UGN5 | 9/20 | 0.77 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.77 |
| ▸ | TNKS | O95271 | 1/20 | 0.77 |
| ▸ | PGR | P06401 | 1/20 | 0.77 |
| ▸ | CDK1 | P06493 | 1/20 | 0.77 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.77 |
| ▸ | POLA1 | P09884 | 1/20 | 0.77 |
| ▸ | PIM1 | P11309 | 1/20 | 0.77 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.77 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.77 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.77 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.77 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.77 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.77 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.77 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.77 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.77 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25956408 | 0.88 | PARP1 (0.60) | PARP1PARP2DYRK3TNKSPGR | |
| Rucaparib SCHEMBL844585 | 0.87 | PARP1 (1.00) | PARP1PARP2DYRK3TNKSPGR | |
| Rucaparib SCHEMBL29351768 | 0.87 | PARP1 (1.00) | PARP1PARP2DYRK3TNKSPGR | |
| Rucaparib SCHEMBL5746065 | 0.86 | PARP1 (0.98) | PARP1PARP2DYRK3TNKSPGR | |
| Rucaparib SCHEMBL29392034 | 0.86 | PARP1 (0.98) | PARP1PARP2DYRK3TNKSPGR | |
| SCHEMBL25008451 | 0.86 | PARP1 (0.57) | PARP1PARP2DYRK3TNKSPGR | |
| SCHEMBL25649903 | 0.85 | PARP1 (0.56) | PARP1PARP2DYRK3TNKSPGR | |
| Rucaparib SCHEMBL5747917 | 0.83 | PARP1 (0.90) | PARP1PARP2DYRK3TNKSPGR | |
| Rucaparib SCHEMBL29379028 | 0.83 | PARP1 (1.00) | PARP1PARP2DYRK3TNKSPGR | |
| Rucaparib SCHEMBL844872 | 0.83 | PARP1 (1.00) | PARP1PARP2DYRK3TNKSPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018122168-A1 | COMBINATIONS OF BUB1 KINASE AND PARP INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-07-05 | — | — | WO | disclosed |