Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20352111 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTMEN1KMT2ATSHR | |
| SCHEMBL21571652 | 0.72 | MAPT (0.54) | SMN1; SMN2MAPTMEN1KMT2ATSHR | |
| SCHEMBL24220513 | 0.72 | HDAC3 (0.48) | SMN1; SMN2MAPTHTTSRPK1CYP2C19 | |
| SCHEMBL20352125 | 0.72 | BACE1 (0.48) | SMN1; SMN2MAPTMEN1KMT2ATSHR | |
| SCHEMBL21571629 | 0.72 | PAICS (0.48) | MEN1KMT2A | |
| SCHEMBL20352114 | 0.71 | PAICS (0.56) | SMN1; SMN2MAPTHTT | |
| SCHEMBL5458260 | 0.70 | NAMPT (0.61) | SMN1; SMN2MAPTMEN1KMT2ATSHR | |
| SCHEMBL458534 | 0.70 | MAPT (0.58) | SMN1; SMN2MAPTMEN1KMT2ATSHR | |
| SCHEMBL15936529 | 0.70 | HDAC1 (0.68) | SMN1; SMN2MAPTMEN1KMT2ATSHR | |
| SCHEMBL6745021 | 0.69 | PDK2 (0.50) | SMN1; SMN2MAPTMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018122549-A1 | OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | LIFEARC (GB) | 2018-07-05 | — | — | WO | disclosed |