Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 9/20 | 0.53 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | ULK1 | O75385 | 3/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2029937 | 0.89 | PTK2 (0.66) | MAPK8PTK2PKMYT1MAPK9MAPK10 | |
| SCHEMBL2030368 | 0.88 | PTK2 (0.61) | PTK2PTK2BCDC7JAK2ROCK2 | |
| SCHEMBL2637710 | 0.83 | PTK2 (0.63) | MAPK8PTK2PKMYT1MAPK9MAPK10 | |
| SCHEMBL23764852 | 0.80 | PTK2 (0.66) | MAPK8PTK2PKMYT1MAPK9MAPK10 | |
| SCHEMBL2034319 | 0.80 | CDC7 (0.56) | PTK2PTK2BCDC7JAK2ROCK2 | |
| SCHEMBL2036906 | 0.80 | PTK2 (0.54) | PTK2PTK2BJAK2JAK3 | |
| SCHEMBL2035650 | 0.80 | PTK2 (0.81) | MAPK8PTK2PKMYT1HDAC3HDAC1 | |
| SCHEMBL30086278 | 0.79 | PTK2 (0.59) | MAPK8PTK2PKMYT1MAPK9MAPK10 | |
| SCHEMBL23754883 | 0.79 | PTK2 (0.59) | MAPK8PTK2PKMYT1MAPK9MAPK10 | |
| SCHEMBL12311812 | 0.78 | MAPK8 (0.61) | MAPK8PTK2PKMYT1MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399433-B2 | Amino pyrimidine anticancer compounds | OSI Pharmaceuticals, LLC (US) | 2013-03-19 | — | — | US | disclosed |
| US-20110136764-A1 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136764-A1 | AMINO PYRIMIDINE ANTICANCER COMPOUNDS | DPYD, PTK2, TYMS | MAPK8 804/4885PTK2 2/4885PKMYT1 247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.