Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 14/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.49 |
| ▸ | CALCA | P06881 | 6/20 | 0.41 |
| ▸ | RAMP1 | O60894 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2031611 | 0.94 | CALCRL (0.56) | CALCRLCYP3A4CALCARAMP1 | |
| SCHEMBL2031917 | 0.93 | CALCRL (0.43) | CALCRLCYP3A4CALCARAMP1 | |
| SCHEMBL3961137 | 0.89 | CALCRL (0.61) | CALCRLCYP3A4CALCARAMP1 | |
| SCHEMBL2032179 | 0.88 | CALCRL (0.48) | CALCRLCYP3A4CALCARAMP1 | |
| SCHEMBL3964432 | 0.83 | CALCRL (0.70) | CALCRLCYP3A4CALCARAMP1 | |
| SCHEMBL3961446 | 0.82 | CALCRL (0.53) | CALCRLCYP3A4CALCARAMP1 | |
| SCHEMBL2030711 | 0.81 | CALCRL (0.65) | CALCRLCYP3A4 | |
| SCHEMBL7144584 | 0.81 | CALCRL (0.53) | CALCRLCYP3A4CALCARAMP1 | |
| SCHEMBL2026964 | 0.81 | CALCRL (0.53) | CALCRLCYP3A4CALCARAMP1 | |
| SCHEMBL3900990 | 0.80 | CALCRL (0.57) | CALCRLCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9585940-B2 | Use of CGRP antagonist compounds for treatment of psoriasis | BIRKIR SVEINSSON (IS) | 2017-03-07 | — | — | US | disclosed |
| US-20140220030-A1 | USE OF CGRP ANTAGONIST COMPOUNDS FOR TREATMENT OF PSORIASIS | SVEINSSON, BIRKIR (IS) | 2014-08-07 | — | — | US | disclosed |
| US-20110150890-A1 | USE OF CGRP ANTAGONIST COMPOUNDS FOR TREATMENT OF PSORIASIS | SVEINSSON BIRKIR | 2011-06-23 | — | — | US | disclosed |
| EP-1556020-B1 | USE OF CGRP ANTAGONIST COMPOUNDS FOR TREATMENT OF PSORIASIS | ACTAVIS GROUP HF (IS) | 2009-02-25 | — | — | EP | disclosed |
| EP-1163239-B1 | MODIFIED AMINO-ACID AMIDES AS CGRP ANTAGONISTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-05-28 | — | — | EP | disclosed |
| US-6313097-B1 | TREATMENT OR PROPHYLAXIS OF MIGRAINE OR CLUSTER HEADACHES, NON-INSULIN-DEPENDENT DIABETES MELLITUS, INFLAMMATION, ALLERGIC RHINITIS, ASTHMA, MORPHINE TOLERANCE, MENOPAUSAL HOT FLASHES, DISEASES CHARACTERIZED BY EXCESSIVE VASODILATATION | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-11-06 | — | — | US | disclosed |