Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 17/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.46 |
| ▸ | BRD2 | P25440 | 4/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.37 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.37 |
| ▸ | CCL2 | P13500 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20357601 | 0.90 | BRD4 (0.54) | BRD4CYP3A4CYP2C9BRD2BRD3 | |
| SCHEMBL20357588 | 0.83 | BRD4 (0.44) | BRD4CYP3A4CYP2C9BRD2BRD3 | |
| SCHEMBL16896881 | 0.83 | BRD4 (0.52) | BRD4CYP3A4CYP2C9BRD2BRD3 | |
| SCHEMBL20357632 | 0.81 | BRD4 (0.54) | BRD4CYP3A4CYP2C9BRD2BRD3 | |
| SCHEMBL20357599 | 0.80 | BRD4 (0.49) | BRD4CYP3A4CYP2C9BRD2BRD3 | |
| SCHEMBL20357573 | 0.80 | BRD4 (0.47) | BRD4CYP3A4CYP2C9BRD2BRD3 | |
| SCHEMBL20357582 | 0.80 | BRD4 (0.47) | BRD4CYP3A4CYP2C9BRD2BRD3 | |
| SCHEMBL20357658 | 0.80 | BRD4 (0.46) | BRD4CYP3A4CYP2C9BRD2BRD3 | |
| SCHEMBL20357610 | 0.80 | BRD4 (0.43) | BRD4CYP3A4CYP2C9BRD2BRD3 | |
| SCHEMBL20357642 | 0.80 | BRD4 (0.46) | BRD4CYP3A4CYP2C9BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | claimed |