Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 16/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.49 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | BRD2 | P25440 | 2/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20357597 | 0.93 | BRD4 (0.44) | BRD4CREBBPNOX4CYP3A4BRD2 | |
| SCHEMBL20357589 | 0.91 | BRD4 (0.46) | BRD4CREBBPNOX4CYP3A4BRD2 | |
| SCHEMBL18317115 | 0.86 | BRD4 (0.50) | BRD4CREBBPNOX4CYP3A4BRD2 | |
| SCHEMBL20357582 | 0.85 | BRD4 (0.47) | BRD4CYP3A4BRD2BRD3CYP2C9 | |
| SCHEMBL20357599 | 0.85 | BRD4 (0.49) | BRD4CREBBPCYP3A4BRD2BRD3 | |
| SCHEMBL20357665 | 0.85 | BRD4 (0.48) | BRD4CREBBPCYP3A4BRD2BRD3 | |
| SCHEMBL20357673 | 0.85 | BRD4 (0.46) | BRD4CYP3A4BRD2BRD3CYP2C9 | |
| SCHEMBL20357601 | 0.84 | BRD4 (0.54) | BRD4CREBBPCYP3A4BRD2BRD3 | |
| SCHEMBL20357587 | 0.84 | BRD4 (0.46) | BRD4CYP3A4BRD2BRD3CYP2C9 | |
| SCHEMBL20357573 | 0.82 | BRD4 (0.47) | BRD4CREBBPCYP3A4BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092227-B1 | BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORP (FI) | 2018-07-11 | — | — | EP | claimed |