Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of Epinephrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 7/20 | 0.90 |
| ▸ | ADRB1 known ✓ | P08588 | 6/20 | 0.90 |
| ▸ | ADRB3 known ✓ | P13945 | 5/20 | 0.90 |
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.90 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.90 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.90 |
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.90 |
| ▸ | ADRA1B known ✓ | P35368 | 3/20 | 0.90 |
| ▸ | ADRA1D known ✓ | P25100 | 2/20 | 0.90 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.90 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.90 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.90 |
| ▸ | MAPT | P10636 | 6/20 | 0.90 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.90 |
| ▸ | TSHR | P16473 | 5/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.90 |
| ▸ | MEN1 | O00255 | 3/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.90 |
| ▸ | MTOR | P42345 | 3/20 | 0.90 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racepinephrine SCHEMBL29396039 | 0.95 | KDM4E (1.00) | KDM4ETDP1ADRB2HIF1AMAPT | |
| [11C]Epinephrine SCHEMBL29371663 | 0.95 | KDM4E (1.00) | KDM4ETDP1ADRB2HIF1AMAPT | |
| Epinephrine SCHEMBL29353423 | 0.95 | KDM4E (1.00) | KDM4ETDP1ADRB2HIF1AMAPT | |
| L-Adrenaline SCHEMBL11647 | 0.95 | KDM4E (1.00) | KDM4ETDP1ADRB2HIF1AMAPT | |
| Racepinephrine SCHEMBL11631789 | 0.95 | KDM4E (1.00) | KDM4ETDP1ADRB2HIF1AMAPT | |
| L-Adrenaline SCHEMBL29519331 | 0.95 | KDM4E (1.00) | KDM4ETDP1ADRB2HIF1AMAPT | |
| Epinephrine SCHEMBL2837188 | 0.95 | KDM4E (1.00) | KDM4ETDP1ADRB2HIF1AMAPT | |
| Racepinephrine SCHEMBL3815 | 0.95 | KDM4E (1.00) | KDM4ETDP1ADRB2HIF1AMAPT | |
| Racepinephrine SCHEMBL20493843 | 0.95 | KDM4E (1.00) | KDM4ETDP1ADRB2HIF1AMAPT | |
| [11C]Epinephrine SCHEMBL29374823 | 0.95 | KDM4E (1.00) | KDM4ETDP1ADRB2HIF1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190209454-A9 | DETERMINATION OF MELANIN INHIBITION POTENTIAL OF NATURAL INGREDIENTS | LUCAS MEYER COSMETICS CANADA, INC. (CA) | 2019-07-11 | — | — | US | disclosed |
| US-20180193248-A1 | DETERMINATION OF MELANIN INHIBITION POTENTIAL OF NATURAL INGREDIENTS | KEMIN IND INC (US) | 2018-07-12 | — | — | US | disclosed |