Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20360735 | 1.00 | ATM (1.00) | ATML3MBTL1MAPTALDH1A1KMT2A | |
| SCHEMBL4141640 | 0.70 | HPGD (0.70) | ATML3MBTL1MAPTALDH1A1KMT2A | |
| SCHEMBL4141641 | 0.70 | HPGD (0.70) | ATML3MBTL1MAPTALDH1A1KMT2A | |
| SCHEMBL10176120 | 0.70 | HPGD (0.70) | ATML3MBTL1MAPTALDH1A1KMT2A | |
| SCHEMBL10971029 | 0.67 | — | — | |
| SCHEMBL10971028 | 0.67 | — | — | |
| Biphenyl SCHEMBL3790238 | 0.67 | GSK3A (0.67) | ATML3MBTL1ALDH1A1GAAHPGD | |
| SCHEMBL3224077 | 0.66 | ATM (0.48) | ATML3MBTL1MAPTALDH1A1KMT2A | |
| SCHEMBL3224073 | 0.66 | ATM (0.48) | ATML3MBTL1MAPTALDH1A1KMT2A | |
| SCHEMBL29961030 | 0.63 | AHR (0.50) | ATML3MBTL1MAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190352297-A1 | SELECTIVE AURORA A KINASE INHIBITORS | UNIVERSITAT BERN (CH) | 2019-11-21 | — | — | US | disclosed |
| WO-2018127292-A1 | SELECTIVE AURORA A KINASE INHIBITORS | Universität Bern (CH) | 2018-07-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190352297-A1 | SELECTIVE AURORA A KINASE INHIBITORS | AURKC, AURKA, AURKB | ATM 350/4885L3MBTL1 398/4885MAPT 2334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.