Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.54 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 9/20 | 0.47 |
| ▸ | JAK3 | P52333 | 9/20 | 0.47 |
| ▸ | JAK1 | P23458 | 5/20 | 0.47 |
| ▸ | EIF2AK4 | Q9P2K8 | 4/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | BLK | P51451 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1996579 | 0.89 | IRAK4 (0.58) | IRAK4IRAK1FLT3JAK2JAK3 | |
| SCHEMBL1997583 | 0.88 | IRAK4 (0.60) | IRAK4IRAK1FLT3JAK2JAK3 | |
| SCHEMBL1996010 | 0.84 | IRAK4 (0.75) | IRAK4IRAK1FLT3JAK2JAK3 | |
| SCHEMBL1990855 | 0.84 | IRAK4 (0.75) | IRAK4IRAK1FLT3JAK2JAK3 | |
| SCHEMBL1993336 | 0.84 | IRAK4 (0.75) | IRAK4IRAK1FLT3JAK2JAK3 | |
| SCHEMBL1996185 | 0.83 | IRAK4 (0.58) | IRAK4IRAK1FLT3JAK2JAK3 | |
| SCHEMBL1996184 | 0.83 | IRAK4 (0.58) | IRAK4IRAK1FLT3JAK2JAK3 | |
| SCHEMBL1994957 | 0.80 | IRAK4 (0.50) | IRAK4IRAK1FLT3EIF2AK4 | |
| SCHEMBL13505191 | 0.80 | IRAK4 (0.50) | IRAK4IRAK1FLT3JAK2JAK3 | |
| SCHEMBL1994606 | 0.78 | IRAK4 (0.49) | IRAK4IRAK1FLT3JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516436-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | Almirall S.A. (ES) | 2012-10-31 | — | — | EP | claimed |
| WO-2011076419-A1 | IMIDAZOPYRIDINE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-06-30 | — | — | WO | claimed |