Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.61 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.54 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.54 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21443236 | 0.93 | ALK (0.61) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL20004642 | 0.93 | ALK (0.63) | ALKSRPK2SRPK1EML4KDR | |
| SCHEMBL20004101 | 0.88 | ALK (0.64) | ALKSRPK2SRPK1EML4KDR | |
| SCHEMBL20004150 | 0.83 | ALK (0.72) | ALKSRPK2SRPK1EML4KDR | |
| SCHEMBL17448454 | 0.83 | ALK (0.54) | ALKSRPK1 | |
| SCHEMBL897264 | 0.81 | ALK (0.70) | ALKSRPK2SRPK1EML4 | |
| SCHEMBL20004141 | 0.81 | ALK (0.63) | ALKSRPK2SRPK1EML4KDR | |
| SCHEMBL16775678 | 0.79 | ALK (0.66) | ALKSRPK2SRPK1EML4KDR | |
| SCHEMBL20004602 | 0.79 | ALK (0.72) | ALKSRPK2SRPK1EML4KDR | |
| SCHEMBL897360 | 0.79 | ALK (0.65) | ALKSRPK2SRPK1EML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613729-A1 | TETRACYCLIC COMPOUNDS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2020-02-26 | — | — | EP | disclosed |
| EP-3345903-B1 | TETRACYCLIC COMPOUNDS | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2019-10-09 | — | — | EP | disclosed |
| EP-3345903-A1 | TETRACYCLIC COMPOUNDS | Chugai Seiyaku Kabushiki Kaisha (JP) | 2018-07-11 | — | — | EP | disclosed |